Dr. Tseng serves as Director of Research & Development of TissueTech, Inc., Medical Director and Consultant of Bio-Tissue, Inc., and Director of Research & Development of Bio-Lipid, Inc.

Dr. Tseng supervises Research Programs,

  • Investigating the pathogenesis of ocular surface and tear diseases
  • Inventing new tools for improving the diagnosis of ocular surface diseases
  • Developing new medical and surgical treatments for ocular surface diseases

Research Team 2008:

  • Scheffer C. G. Tseng, M.D., Ph.D., Director
  • Topaz Kirlew, DBA, MT(ASCP), Executive VP Technical & Clinical Affairs
  • Yvette Blanco-Jivanjee, M.S., Regulatory Affairs Manager
  • Shuangling Chen, Ph.D., OSREF Scholar (China)
  • Szu-Yu Chen, M.S., Research and Product Development Specialist
  • Hua He, Ph.D., Senior Research Scientist
  • Jianjing Li, M.D., OSREF Scholar (China)
  • Lingyi Liang, M.D., OSREF Scholar (China)
  • Elizabeth Shay, B.S., Research and Product Development Specialist
  • Hosam Sheha, M.D., Ph.D., Consultant of Ophthalmology
  • Ek Kai Tan, B.S., Junior Research and Product Development
  • John Zhang, Ph.D., Senior Research and Product Development Specialist
  • Ying-Ting Zhu, Ph.D., Senior Research Specialist
Research Fellows of 2004 Research Team at BT in 2004
Dr. Sun and Dr. Tseng 2002

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  • Tung-Tien Sun, Ph.D.
    Ruldof L. Baer Professor, Department of Dermatology,
    New York Univeristy School of Medicine
  • Winston W-Y Kao, Ph.D.
    Professor, Department of Ophthalmology, University of Cincinnati


  • Jean-Marie Parel, Ph.D.
    Henri and Flore Lesieur Chair Professor, Department of Ophthalmology,
    Bascom Palmer Eye Institute, University of Miami School of Medicine
  • Susanne Binder, M.D.
    Professor & Chair, Department of Ophthalmology,
    Rudolph Foundation Hospital, Vienna, Austria
  • Kazuo Tsubota, M.D.
    Professor & Chairman, Department of Ophthalmology
    Keio University, Tokyo, Japan
  • Chia-yang Liu, Ph.D.
    Assistant Professor, Bascom Palmer Eye Institute
    Department of Ophthalmology, University of Miami
  • Gisele Li, M.D., FRCSC, DABO
    Assistant Professor
    University of Montreal, Quebec
  • Brian A. Francis, M.D., M.S.
    Associate Professor of Ophthalmology
    Doheny Eye Center
  • Shachar Tauber, M.D.
    Director of Ophthalmology Research
    Cornea and Refractive Surgery
    Department of Ophthalmology/Optometry
    St. John’s Hospital and Clinics
  • Zuguo Liu, M.D., Ph.D.
    Professor, Director
    Eye Institute of Xiamen
    Xiamen University School of Medicine
  • Wei Li, M.D.
    Associate Professor
    Eye Institute of Xiamen
    Xiamen University School of Medicine
  • Ira J Udell, M.D.
    Vice Chairman
    Department of Ophthalmology
    North Shore-Long Island Jewish Health System
  • Ines Velez, D.P.S., M.S.
    Associate Professor
    Department of Diagnostic Sciences
    College of Dental Medicine
    Nova Southeastern University
  • Kraig S. Bower, M.D., F.A.C.S.
    Center for Refractive Surgery
    Ophthalmology Service
    Walter Reed Army Medical Center
Dr. Parel and Dr. Tseng 2001 Dr. Tsubota and Dr. Tseng 2001

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Basic Research Projects

  • Exploring the action mechanism of amniotic membrane transplantation with respect to its anti-scarring, anti-inflammatory, and anti-angiogenic effects
  • Exploring the mechanism of corneal invasion of pterygium
  • Exploring the mechanism of recurrence of pterygium
  • Exploring the mechanism of connective tissue laxity in conjunctivochalasis
  • Exploring the mechanism by which amniotic membrane supports and expand epithelial stem cells
  • Identifying markers for epithelial stem cells
  • Exploring the mechanism by which limbal stem cell deficiency develops
  • Developing new tissue engineering products using amniotic membrane matrix
  • Testing gene therapies targeted at the epithelial stem cells
  • Exploring ex vivo expansion of RPE cells on amniotic membrane
  • Exploring new therapies to control conjunctival inflammation
  • Exploring the role of epithelial-mesenchymal interactions in wound healing
  • Developing Kinetic analysis of tear interference images to diagnose lipid tear deficiency
  • Exploring new treatments of meibomian gland dysfunction
  • Exploring how amniotic membrane matrix can be used to maintain the cell phenotype of such mesenchymal cells as keratocytes
  • Exploring the anti-scarring mechanism of amniotic membrane matrix

Clinical Research Projects

  • Reviewing clinical data of amniotic membrane transplantation and keratolimbal allograft help patients with limbal stem cell deficiency using a new immunosuppression regimen
  • Reviewing surgical videos to see how surgical procedures of various reconstruction procedures are performed.
  • Reviewing Impression cytology data concerning its use in diagnosing ocular surface disorders including limbal stem deficiency
  • Development and testing a new synthetic meibum lipid formulation for treating lipid tear deficiency
  • Testing how kinetic analysis of tear interference can be used to diagnose lipid tear deficiency
  • Exploring blink-related microtrauma as a new pathogenic factor for ocular surface diseases
  • Exploring whether acute tarsal ulceration is the key reason of developing cicatricial complications on the cornea in Stevens Johnson syndrome
  • Exploring new surgical strategies to deepen the fornix
  • Exploring the new surgical strategies to restore the lacrimal gland function in cicatricial ocular surface diseases

    [Note]: Foreign scholars (fellows) will only participate in data analysis or review of current data collected in basic research or previous clinical research. There is no direct patient care.

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Research Supports

  • TissueTech, Inc.
    Research & Development Grant
  • Ocular Surface Research and Education Foundation (OSREF) Grant

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